The Ghost Woman is the boss of the first area of the game. In the opening cutscene, Ebisumaru comes to inform Goemon of her sudden appearance in Horo Temple at the north part of town, and both set on their way to stop her (which actually triggers the rest of the events in the game to unfold).
She attacks by flying about and sending several flying spinning plates all across the screen. Being a ghost, she is incorporeal and cannot be physically harmed. The player has to hit the ghostly spinning plates and send them flying back at her in order to deal damage.
The Ghost Woman makes a brief cameo reminiscent of her appearance in The Legend of the Mystical Ninja, although it once again happens to be a shapeshifting Kurobei somewhat reprising his role in the aforementioned game. After the initial scare, he once again gives our heroes insight on the current situation.
The Ghost Woman appears as the second boss in the "Boss Rush" stage of the Super Famicom version of this game. Her weak point is her head and she can only be hurt while she is not attacking.
She shares the same boss theme from her appearance in The Legend of the Mystical Ninja, and makes the same noise and special effect when she appears as she did in that game.
She has three attacks, all of which involve the plates she is spinning. These cannot be destroyed.
- Blue plates - Flung in the direction of the player.
- Yellow plates - Flung in random directions and they bounce off the side of the screen. She is invulnerable during this phase of the battle.
- Red plates - Only two of these are sent at once, and they home toward and follow the player. They will eventually leave the screen on their own.
- Tsurami, a boss appearing in Mystical Ninja Starring Goemon, is a giant robot based on the Ghost Woman.